Saturday, December 17, 2011

The Ethics of Embryonic Stem Cell Research


            In recent years modern medical technology has advanced by leaps and bounds. There have been many new technologies and new developments. One such area of recent scientific development is stem cell therapy. Stem cell therapy is a very promising area of research. Research has indicated that stem cells could be used in the treatment (and even cure) of disease such as Alzheimer’s, diabetes, cancer, Parkinson’s disease and paralysis. Many scientists have heralded this research as the next, up-and-coming ‘wonder drug’. However, this emerging technology is not without it’s ethical concerns. Before diving into the ethical concerns surrounding stem cell therapy it is important to have a basic understanding of exactly what stem cells are and what stem cell therapy is. To put it succinctly, stem cells are cells that have not differentiated. Differentiation is the process a cell goes through to become specialized. There are over two hundred different types of cells in the human body and they all have their origin in stem cells. Every cell in the human body starts out as a stem cell. Stem cells have three general properties: they are capable of dividing and renewing themselves for long periods; they are unspecialized; and they can give rise to specialized cell types (“Stem Cell Basics”). There are many different types of stem cells. All stem cells fall under two broad categories; adult (tissue specific) stem cells and embryonic stem cells. Embryonic stem cells can differentiate into any type of cell in the body; they are referred to as Pluripotent stem cells. Conversely, adult stem cells are much more limited in their ability to differentiate, thusly they are called multipotent stem cells. Induced pluripotent cells are non-pluripotent cells that were engineered (‘induced’) to become pluripotent, that is, able to form all cell types of the body. In other words, a cell with a specialized function (for example a skin cell) was ‘reprogrammed’ to an unspecialized state similar to that of an embryonic stem cell. While IPS cells and embryonic stem cells share many characteristics they are not identical (“An Overview of Stem Cell Research”).
            Adult stem cells have been used in the treatment of many different diseases for a great number of years. Bone marrow contains blood-forming stem cells (hematopoietic stem cells) that have been used for decades to treat blood cancers and other blood disorders. Umbilical cord blood is another source of hematopoietic stem cells that is being used in treatment.
            There are very few ethical concerns arising from the use of adult stem cells for research, beyond the normal ethical concerns involved in research. However, that is most certainly not the case with human embryonic stem cells (hESC). Currently, research on embryonic stem cells may well be one of the most hotly contested ethical dilemmas in healthcare. Despite this, there is very little real understanding of the heart of the issue. In order to fully grasp the ethical quandaries presented by hESC research it is imperative to have a scientific understanding of exactly what is occurring during research. As we have already discussed, a stem cell is an undifferentiated cell. The National Institute of Health (NIH) defines human embryonic stem cells (hESC) as cells “that are derived from the inner cell mass of blastocyst stage human embryos, are capable of dividing without differentiating for a prolonged period in culture, and are known to develop into cells and tissues of the three primary germ layers.” A human being is considered an embryo from conception through the end of the second month. In order to manufacture hESC, scientists create an embryo (or use one left over from IVF), and after it undergoes several cycles of division they extract the stem cells. The extraction of the stem cells necessitates the destruction of the embryo. It is this fact that is the key issue of the hESC debate. The entire debate hinges on this one question: “is an embryo a human life?”
            The Britannica academic edition online defines biologic life as “Matter characterized by the ability to metabolize nutrients (process materials for energy and tissue building), grow, reproduce, and respond and adapt to environmental stimuli.” An embryo fits this description for the moment of conception. So we know that an embryo is alive, now is it a human life? Each human embryo contains the DNA to become a genetically distinct human life. It would be unethical to define human life by age, developmental status, usefulness, or ‘wantedness’. Therefore, an embryo being by definition alive and by genetic design a human, is a human life worthy of protection. Human life is priceless, from the very moment of conception to the last breath. The creation and destruction of human embryos violates every single ethical criterion. It goes against nonmalevoelce (do no harm) as it kills a living human being. It also defies autonomy, as that embryo does not have a say in what is happening to it. It defies benevolence for obvious reasons and well as Justice. Where is the justice in killing a child before it’s even a week old? There is therefore no ethical way to use hESC for research. To deny that the prospects of hESC research is anything less than thrilling would be futile, nonetheless it is vital that we tread with caution. It is imperative for the sake of our generation and future generations that we continue to uphold the ethical and moral principles that have held our society together. To abandon our integrity for any reason is to step unto the path of self-destruction.
            The question remains as to what to do with the surplus of human embryos left over from IVF and other fertility treatments. As we have already discussed, using human embryos for research is unethical. Different pro-life ethicist have come up with solutions one such solution is to place the embryos up for adoption. Several organizations have been created for this purpose.
            In conclusion, creating human life for the specific purpose of destroying it or performing experiments on it is grotesque. Doing the wrong thing in hopes of achieving the right outcome is never acceptable. People have used the argument of ‘the end justifies the means’ to justify many inhumane, horrific acts. As a nation it is imperative that we do not give into the pressure to compromise our values for the sake of finances. The maintenance of integrity is worth every cost and every sacrifice. If we are to survive as a nation it is imperative that we protect the sanctity of human life, at all stages of development.

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